MGST1 and ATG16L1 overexpression, and MGST1 depletion assay were conducted by Medicilon.

TRIM24 (tripartite motif-containing protein 24) and BRPF1 (bromodomain and PHD finger containing protein 1) are epigenetics “readers”and potential therapeutic targets for cancer and other diseases. Y0

Pan-bromodomain and extra terminal (Pan-BET) inhibitors show profound efficacy but exhibit pharmacology-driven toxicities in clinical trials. The representative Compound 8l (XY153), a novel BD2-select

Uncovering new therapeutics for kidney fibrosis hold promise for chronic kidney disease (CKD). BRD4 inhibition ameliorated kidney injury and fibrosis. ZLD2218 exhibited the potent inhibitory activity

TOP5300 is an orally active follicle stimulating hormone receptor allosteric agonist that provides a preferred treatment for over 16 million infertile women of reproductive age in low complexity metho

Poly ADP-ribose polymerases (PARPs) are a family of enzymes related to DNA damage repair process.?Inhibition of PARP1/2 accelerates the damage of injured DNA, which is synthetically lethal to DNA

The inhibition of HDACs will lead to compensated activation of a notorious cancer-related drug target, STAT3, in breast cancer through a cascade, which probably limits the anti-proliferation effect of

Tankyrase 1 and 2 (TNKS1/2) impact the WNT/β-catenin and Hippo signaling pathways that are involved in numerous human disease conditions including cancer. OM-153 shows picomolar IC50 inhibition in a c

The binding assay by surface plasmon resonance (SPR) analysis shows that WYC-209A and WYC-209B acid bind to RARs at nano-molar doses. SPR was carried out by Medicilon, using the Biacore 8K equipment.

TTK inhibition is an attractive wide-spectrum strategy for cancer therapy. Researchers designed and synthesized a series of pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable TTK inhibitors. All the pharmacokinetic studies were carrie

Immune checkpoint inhibition therapies have been used for multiple cancer research. H11-HLE is a tool molecule that allows the interrogation of the contribution of Fc in mediating immune checkpoint therapy. Half-life extended H11 (H11-HLE) induces potent

JND003 is orally bioavailable and exhibits high grade of distribution in liver and abdominal adipose tissues. Pharmacokinetics (PK) and Tissue Distribution Assays of JND003 were performed at Medicilon.

美迪西藥代動力學(xué)與生物分析部主任章登吉博士將在藥代動力學(xué)研究方法與應(yīng)用技術(shù)交流會上做“高靈敏度Assay在大分子藥代動力學(xué)研究中的應(yīng)用”演講報(bào)告，歡迎觀看直播。

美迪西生物部主任毛卓博士做客云講堂，通過真實(shí)案例深入探討了PROTAC體外實(shí)驗(yàn)在構(gòu)效關(guān)系研究中的應(yīng)用，以及體外assay在推動臨床在研PROTAC分子進(jìn)程中的關(guān)鍵作用。

7月14日19：00，美迪西生物部主任毛卓博士將做客云講堂，以《如何選擇合適的體外assay進(jìn)行PROTAC分子構(gòu)效關(guān)系研究》為主題，探究PROTAC的最新研究進(jìn)展、PROTAC技術(shù)當(dāng)前挑戰(zhàn)和未來趨勢，通過真實(shí)案例探討各種PROTAC體外實(shí)驗(yàn)在構(gòu)效關(guān)系研究中的應(yīng)用、體外assay在臨床在研PROTAC分子推進(jìn)過程中的應(yīng)用等，并分享美迪西PROTAC服務(wù)平臺是如何助力客戶加速研發(fā)進(jìn)程的，用豐富的團(tuán)隊(duì)實(shí)戰(zhàn)經(jīng)驗(yàn)為您的研發(fā)答疑解惑！

7月14日19：00，美迪西生物部主任毛卓博士將做客云講堂，以《如何選擇合適的體外assay進(jìn)行PROTAC分子構(gòu)效關(guān)系研究》為主題，探究PROTAC的最新研究進(jìn)展、PROTAC技術(shù)當(dāng)前挑戰(zhàn)和未來趨勢，通過真實(shí)案例探討各種PROTAC體外實(shí)驗(yàn)在構(gòu)效關(guān)系研究中的應(yīng)用、體外assay在臨床在研PROTAC分子推進(jìn)過程中的應(yīng)用等，并分享美迪西PROTAC服務(wù)平臺是如何助力客戶加速研發(fā)進(jìn)程的，用豐富的團(tuán)隊(duì)實(shí)戰(zhàn)經(jīng)驗(yàn)為您的研發(fā)答疑解惑！

抗體藥物體內(nèi)的多種存在形式使得其PK分析方法學(xué)設(shè)計(jì)較為復(fù)雜，如何考慮待測分子形式，如何針對性地設(shè)計(jì)出合適的Assay Format，實(shí)踐中又可能出現(xiàn)什么樣的問題和挑戰(zhàn),在本文中美迪西藥代動力學(xué)與生物分析部主任章登吉博士將進(jìn)行詳細(xì)闡述。