美迪西請(qǐng)回答為您列舉了一些傾向于發(fā)生油析的化合物類型：熔點(diǎn)相對(duì)較低、相對(duì)分子量較大、分子中含有柔性結(jié)構(gòu)、糖類化合物、吸水性較大的化合物。

SAHA was synthesized by Medicilon and was given to mice as 50?mg/kg doses. Injections (10?mL/kg) were given intraperitoneally and were alternated daily between left and right sides of the abdomen. Chronic treatments of SAHA completely restored performance

OHD (purity >99 %) was synthesized by Medicilon. Medicilon synthetic chemistry team is capable of the independent design of synthesis pathways and complex compound treatments, key to helping accelerate drug discovery.

The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. 6-Ethynyl-1H-indole derivative 55 is a potent and selective PAK4 inhibitor (Ki=10.2 nM). Compound 55 is effective in the treatment of metastatic

美迪西的合成化學(xué)服務(wù)將有機(jī)化學(xué)知識(shí)與技巧深入靈活的運(yùn)用、合理高效地設(shè)計(jì)化合物合成路徑、保護(hù)客戶的IP相關(guān)權(quán)益并保證數(shù)據(jù)的真實(shí)完整性。 藥物化學(xué) 化學(xué)和生物學(xué)深度交叉指導(dǎo)每個(gè)項(xiàng)目 廣泛運(yùn)用先進(jìn)的藥物發(fā)現(xiàn)技術(shù) 在創(chuàng)新設(shè)計(jì)和專利戰(zhàn)略方面的豐富經(jīng)驗(yàn) 響應(yīng)式的項(xiàng)目管理方法和有效的溝通 生物學(xué) 豐富的知識(shí)儲(chǔ)備與項(xiàng)目經(jīng)驗(yàn) 新技術(shù)的快速跟進(jìn)與應(yīng)用 多種熱門靶點(diǎn)測(cè)試

美迪西的綜合研發(fā)服務(wù)涵蓋醫(yī)藥臨床前新藥研究的全過(guò)程，包括化合物合成、化合物活性篩選、結(jié)構(gòu)生物學(xué)、CMC、藥動(dòng)力學(xué)評(píng)價(jià)、藥代動(dòng)力學(xué)、藥物安全性評(píng)價(jià)和IND注冊(cè)申報(bào)服務(wù)。

美迪西化學(xué)部是一支專業(yè)過(guò)硬，高效有素的研發(fā)團(tuán)隊(duì)。以馬興泉博士為首的科研團(tuán)隊(duì)建立了PROTAC藥物發(fā)現(xiàn)技術(shù)平臺(tái)，建立了linker系統(tǒng)，掌握了如何利用時(shí)下熱門的智能AI技術(shù)設(shè)計(jì)化合物合成路線，大大改進(jìn)和提高合成化學(xué)效能。