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HB0052在美國獲批臨床，不僅開啟華奧泰全球化戰(zhàn)略的關(guān)鍵一步，硬核展現(xiàn)了華奧泰深厚的自主研發(fā)和技術(shù)創(chuàng)新實力，以及完善的抗體偶聯(lián)藥物研發(fā)平臺，也是美迪西抗體藥物偶聯(lián)物（ADC）研發(fā)服務(wù)平臺快速落地的又一個成功案例。

此次GT929新藥實現(xiàn)中美雙報雙批，再次驗證和體現(xiàn)了標(biāo)新生物GLUETACS?平臺快速發(fā)現(xiàn)候選藥物和管線推進的能力，也是標(biāo)新生物全球化進程的又一里程碑。

此次LX-132獲批臨床，顯示了力鑫生物在小分子共價抑制劑創(chuàng)新藥研發(fā)領(lǐng)域的創(chuàng)新能力，也再次驗證了美迪西一站式生物醫(yī)藥臨床前研發(fā)服務(wù)平臺的賦能實力。

Replication stress (RS) is a cancer hallmark; chemotherapeutic drugs targeting RS are widely used as treatments for various cancers. To develop next-generation RS-inducing anticancer drugs, cell division cycle 7 (CDC7) has attracted attention as a target. Researchers have developed an oral CDC7-selective inhibitor, TAK-931, as a candidate clinical anticancer drug. TAK-931 demonstrated marked, dose-dependent antitumor activity, without severe body weight loss. Antitumor efficacy studies for TAK-931 were carried out in two pancreatic PDX models, PHTX-249Pa and PHTXM-97Pa, at Medicilon.

此次ABM-1310獲美國FDA孤兒藥資格認證，不僅顯現(xiàn)了璧辰醫(yī)藥全球化創(chuàng)新的不凡實力，也表現(xiàn)了其在小分子入腦藥物領(lǐng)域的領(lǐng)軍地位。

YY201獲得臨床獲批不僅代表了宇耀生物又一重要突破，驗證了宇耀生物超級分子膠技術(shù)平臺和AI藥物輔助開發(fā)平臺的創(chuàng)新能力，同時也證明了美迪西臨床前研究的技術(shù)服務(wù)力量。

美迪西為NB002提供了安全性評價、藥代動力學(xué)等臨床前研究服務(wù)，助力其IND申請順利獲FDA臨床許可。

美迪西為BIOT-001的研發(fā)提供了從靶點到IND申報的臨床前研發(fā)服務(wù)，全力促成該項目高質(zhì)高效完成。

?Alzheimer's disease (AD) is the most universal age-related neurodegenerative disease. AP39 is a newly synthesized mitochondrially targeted H2S donor on mitochondrial function. AP39 increases intracellular H2S levels, mainly in mitochondrial regions. AP39 exerts dose-dependent effects on mitochondrial activity in APP/PS1 neurons. AP39, a novel mitochondria-targeted H2S donor, was designed and synthesized by Medicilon.

Alzheimer's disease (AD) is a progressive and devastating neurodegenerative disorder, characterized by the presence of β-amyloid (Aβ) peptide plaques, neurofibrillary tangles, and neuroinflammation. Receptor for advanced glycation end products (RAGE) belongs to the immunoglobulin superfamily, which functions as a cell surface acceptor for Aβ peptide. RAGE plays an important role in the Aβ-mediated neuronal damage that closely related to the pathogenesis of AD. In this study, Compound 12 showed good dual-target bioactivities against RAGE and SERT in vitro, good liver microsomal stability, and acceptable pharmacokinetic properties. Pharmacokinetic studies were commissioned by Medicilon.