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TTK inhibition is an attractive wide-spectrum strategy for cancer therapy. Researchers designed and synthesized a series of pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable TTK inhibitors. All the pharmacokinetic studies were carried out by Medicilon.

The pharmacokinetic properties of TR‐107 were compared with other known ClpP activators including ONC201 and ONC212. TR‐107 displayed excellent exposure and serum t1/2 after oral administration. Pharmacokinetic analysis were evaluated for pharmacokinetic properties in ICR mice by Medicilon.

SKLB-197, exhibits good pharmacokinetic properties, could be a promising lead compound for drug discovery targeting ATR. The pharmacokinetic (PK) studies were performed by Medicilon.

Immune checkpoint inhibition therapies have been used for multiple cancer research. H11-HLE is a tool molecule that allows the interrogation of the contribution of Fc in mediating immune checkpoint therapy. Half-life extended H11 (H11-HLE) induces potent anti-tumor efficacy in mouse syngeneic tumor models.

Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent forms of chronic liver diseases. Estrogen-related receptor alpha (ERRα) is a viable target for NAFLD.

Psoriasis is a common immune-mediated skin disorder manifesting in abnormal skin plaques, and PDE4 is an effective target for the treatment of inflammatory diseases such as psoriasis.

The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. 6-Ethynyl-1H-indole derivative 55 is a potent and selective PAK4 inhibitor (Ki=10.2 nM). Compound 55 is effective in the treatment of metastatic cancer. The pharmacokinetic study of Compound 55 was carried out by Medicilon.

這是德睿智藥對人工智能結(jié)合藥物研發(fā)技術(shù)不斷地嘗試、探索和創(chuàng)新的成果，也讓德睿智藥成為全球范圍內(nèi)為數(shù)不多的臨床階段AI制藥公司之一。同時，此次美迪西與德睿智藥的成功合作，也反映出CRO與AI公司為新藥研發(fā)提速、增效、降本。

祝賀拓領(lǐng)博泰TollB-001片獲FDA臨床試驗批準(zhǔn)！這是拓領(lǐng)博泰團(tuán)隊近二十年的免疫調(diào)控機理研究和免疫調(diào)控藥物研究的厚積薄發(fā)，也是美迪西藥學(xué)研究CDMO服務(wù)平臺的又一次成功經(jīng)驗積淀。

美迪西將持續(xù)拓展眼科藥物領(lǐng)域的創(chuàng)新技術(shù)，助力更多眼科藥物跑出研發(fā)“加速度”！