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搜索結(jié)果包含 maximum tolerated dose 的內(nèi)容

Jul 06,2023
PTX-HSN是一種高效納米系統(tǒng),具有較高耐受劑量,可將PTX遞送至卵巢癌并增強(qiáng)主動(dòng)腫瘤靶向性。此研究中所有體內(nèi)實(shí)驗(yàn)均通過(guò)美迪西進(jìn)行
Paclitaxel-loaded hyaluronan solid nanoemulsions (PTX-HSNs) were successfully fabricated for the delivery of PTX to improve ovarian cancer treatment via active tumor targeting. The in vivo #toxicity,
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PTX-HSN是一種高效納米系統(tǒng),具有較高耐受劑量,可將PTX遞送至卵巢癌并增強(qiáng)主動(dòng)腫瘤靶向性。此研究中所有體內(nèi)實(shí)驗(yàn)均通過(guò)美迪西進(jìn)行
Jul 06,2023
研究人員成功發(fā)現(xiàn)了一種口服PROTAC降解劑SIAIS164018,具有良好的體內(nèi)耐受性。PK和MTD研究通過(guò)美迪西進(jìn)行
PROTAC is an attractive technology in drug discovery. Researchers successfully discovered an orally available PROTAC degrader SIAIS164018 which degrades not only ALK or mutant EGFR but also oncoprotei
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研究人員成功發(fā)現(xiàn)了一種口服PROTAC降解劑SIAIS164018,具有良好的體內(nèi)耐受性。PK和MTD研究通過(guò)美迪西進(jìn)行
Jun 28,2023
SAHA可有效恢復(fù)阿爾茨海默病模型的記憶能力,本研究中SAHA通過(guò)美迪西合成
SAHA was synthesized by Medicilon and was given to mice as 50?mg/kg doses. Injections (10?mL/kg) were given intraperitoneally and were alternated daily between left and right sides of the abdomen. Chronic treatments of SAHA completely restored performance
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SAHA可有效恢復(fù)阿爾茨海默病模型的記憶能力,本研究中SAHA通過(guò)美迪西合成
Jun 28,2023
法尼基轉(zhuǎn)移酶抑制劑LNK-754單次口服后即可快速穿過(guò)血腦屏障,本研究中PK分析通過(guò)美迪西進(jìn)行
Pharmacokinetic studies revealed that after a single oral dose, the FTI (LNK-754) was cleared from plasma within 20 hours and could rapidly cross the blood-brain-barrier. Pharmacokinetic analysis was performed as a service provided by Medicilon.
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法尼基轉(zhuǎn)移酶抑制劑LNK-754單次口服后即可快速穿過(guò)血腦屏障,本研究中PK分析通過(guò)美迪西進(jìn)行
Jun 28,2023
WYC-209可抑制惡性小鼠黑色素瘤腫瘤再生細(xì)胞增殖,本研究中SPR通過(guò)美迪西使用Biacore 8K進(jìn)行
The binding assay by surface plasmon resonance (SPR) analysis shows that WYC-209A and WYC-209B acid bind to RARs at nano-molar doses. SPR was carried out by Medicilon, using the Biacore 8K equipment.
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WYC-209可抑制惡性小鼠黑色素瘤腫瘤再生細(xì)胞增殖,本研究中SPR通過(guò)美迪西使用Biacore 8K進(jìn)行
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