?Despite progress in the treatment of T-cell acute lymphoblastic leukemia (T-ALL) has limited treatment options, particularly in the setting of relapsed/refractory disease. Researchers used SHMT1/2 inhibitor RZ-2994 to characterize the effect of inhibiting SHMT1/2 in T-ALL. Loss of both SHMT1/2 is necessary for impaired growth and cell cycle arrest, with suppression of SHMT1/2 inhibiting leukemia progression. RZ-2994 also decreases leukemia burden in vivo. RZ-2994 was obtained from Medicilon. Medicilon offers a full range of chemical services covering all phases of your project. Customers can work with us either through FFS or FTE.

Caco-2細(xì)胞滲透性試驗(yàn)可以提供有關(guān)化合物在模擬腸道條件下的吸收特性的重要信息。通過測量化合物通過細(xì)胞層的能力，評估其被吸收到循環(huán)系統(tǒng)中的潛力，并預(yù)測其在體內(nèi)的藥代動力學(xué)行為。